Genetic Testing for Inherited Susceptibility to Colon Cancer, Including Microsatellite Instability Testing
ثبت نشده
چکیده
The following Protocol contains medical necessity criteria that apply for this service. It is applicable to Medicare Advantage products unless separate Medicare Advantage criteria are indicated. If the criteria are not met, reimbursement will be denied and the patient cannot be billed. Preauthorization is required.* Please note that payment for covered services is subject to eligibility and the limitations noted in the patient’s contract at the time the services are rendered.
منابع مشابه
Genetic Testing for Inherited Susceptibility to Colon Cancer, Including Microsatellite Instability Testing
متن کامل
WHO histological classification of tumours of the colon and rectum
Colorectal carcinomas vary considerably throughout the world, being one of the leading cancer sites in the developed countries. Both environmental (diet) and genetic factors play key roles in its aetiology. Genetic susceptibility ranges from well-defined inherited syndromes, e.g. familial adenomatous polyposis, to ill-defined familial aggregations. Molecular genetic mechanisms are diverse, and ...
متن کاملMolecular Analysis of Microsatellite Instability in Hereditary Non Polyposis Colon Carcinoma Patients from North-East Iran
Background and Objectives: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by germ-line mutations in DNA mismatch repair genes. Tumors arising as a result of these mutations display instability in a sequence area known as microsatellites. Studies have shown that some Bethesda markers (BAT25, BAT26) are more efficient than other...
متن کاملBowel cancer in a 17 year old: what could be the reason?
Inherited conditions predisposing to early onset bowel cancer include the autosomal dominant conditions of Lynch Syndrome, Familial Adenomatous Polyposis and PTEN Hamartoma Tumor Syndrome, as well as the autosomal recessive condition of MUTYH-Associated Polyposis. There is also an increased risk of early onset bowel cancer and other malignancies in individuals with biallelic mutations (homozygo...
متن کاملDeficient mismatch repair: Read all about it (Review)
Defects in the DNA mismatch repair (MMR) proteins, result in a phenotype called microsatellite instability (MSI), occurring in up to 15% of sporadic colorectal cancers. Approximately one quarter of colon cancers with deficient MMR (dMMR) develop as a result of an inherited predisposition syndrome, Lynch syndrome (formerly known as HNPCC). It is essential to identify patients who potentially hav...
متن کامل